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Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

Renal ATP production primarily relies on oxidative phosphorylation of major nutrients in the mitochondria, supplemented by a minor contribution from glycolysis

However, functionality of the enzymes encoded by these genes remains to be verified

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